Methods
Techniques
We employ a multi-disciplinary approach combining cutting-edge recording technologies with sophisticated computational analysis to dissect neural circuits.
In Vivo Electrophysiology
We perform large-scale extracellular recordings using high-density silicon probes (Neuropixels) to monitor the activity of hundreds of neurons simultaneously in behaving animals. This allows us to track neural dynamics across multiple brain regions with millisecond precision.
Biosensor Imaging
We use 1-photon and 2-photon imaging to visualize the activity of genetically defined neuronal populations. By expressing fluorescent indicators (such as GCaMP, dLight, GRAB sensors), we can track the activity of specific cell types or neuromodulatory signalsduring complex behaviors.
Computational Modeling
We develop reinforcement learning agents and neural network models to generate testable hypotheses about neural computation. We compare model behavior and internal representations with experimental data to understand the algorithms implemented by the brain.
Want to learn these techniques?
We welcome motivated researchers who want to develop expertise in these cutting-edge approaches.
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